False Memory Confidence Depends on the Prefrontal Reinstatement of True Memory

Abstract

For confidence of memory, a neural basis such as traces of stored memories should be required. However, because false memories have never been stored, the neural basis for false memory confidence remains unclear. Here we monitored the brain activity in participants while they viewed learned or novel objects, subsequently decided whether each presented object was learned and assessed their confidence levels. We found that when novel objects are presented, false memory confidence significantly depends on the shared representations with learned objects in the prefrontal cortex. However, such a tendency was not found in posterior regions including the visual cortex, which may be involved in the processing of perceptual gist. Furthermore, the confidence-dependent shared representations were not observed when participants correctly answered novel objects as non-learned objects. These results demonstrate that false memory confidence is critically based on the reinstatement of high-level semantic gist of stored memories in the prefrontal cortex.