Microfluidic vascular models of tumor cell extravasation

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<jats:p>Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These <jats:italic>in vitro</jats:italic> technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at the site of the metastatic tumor. To date, extensive efforts have been made to capture key features of the microvasculature to reconstitute the pre-metastatic niche and investigate dynamic extravasation behaviors using microfluidic systems. In this mini-review, we highlight recent microfluidic vascular models of tumor cell extravasation and explore how this approach contributes to development of <jats:italic>in vitro</jats:italic> disease models to enhance understanding of metastasis <jats:italic>in vivo</jats:italic>.</jats:p>
Publisher
FRONTIERS MEDIA SA
Issue Date
2022-11
Language
English
Article Type
Review
Citation

FRONTIERS IN ONCOLOGY, v.12

ISSN
2234-943X
DOI
10.3389/fonc.2022.1052192
URI
http://hdl.handle.net/10203/301358
Appears in Collection
ME-Journal Papers(저널논문)
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