DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Incheol | ko |
dc.contributor.author | Park, Yeonkyoung | ko |
dc.contributor.author | Seo, Jwa-Won | ko |
dc.contributor.author | Park, Ok Hyun | ko |
dc.contributor.author | Ha, Hongseok | ko |
dc.contributor.author | Nam, Jin-Wu | ko |
dc.contributor.author | Kim, Yoon Ki | ko |
dc.date.accessioned | 2022-08-04T07:00:19Z | - |
dc.date.available | 2022-08-04T07:00:19Z | - |
dc.date.created | 2022-08-04 | - |
dc.date.created | 2022-08-04 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | FASEB JOURNAL, v.33, no.2, pp.2680 - 2693 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297796 | - |
dc.description.abstract | All metazoan mRNAs have a poly(A) tail at the 3 end with the exception of replication-dependent histone (RDH) mRNAs, which end in a highly conserved stem-loop (SL) structure. However, a subset of RDH mRNAs are reported to be polyadenylated under physiologic conditions. The molecular details of the biogenesis of polyadenylated RDH [poly(A)(+) RDH] mRNAs remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)(+) RDH mRNAs, relative to canonical RDH mRNAs, which end in an SL structure. We demonstrate that the stabilization of poly(A)(+) RDH mRNAs occurs in a translation-independent manner and is regulated via human antigen R (HuR) binding to the extended 3 UTR under stress conditions. Our data suggest that HuR regulates the expression of poly(A)(+) RDH mRNAs.Ryu, I., Park, Y., Seo, J.-W., Park, O. H., Ha, H., Nam, J.-W., Kim, Y. K. HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions. | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions | - |
dc.type | Article | - |
dc.identifier.wosid | 000457296600092 | - |
dc.identifier.scopusid | 2-s2.0-85061059167 | - |
dc.type.rims | ART | - |
dc.citation.volume | 33 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 2680 | - |
dc.citation.endingpage | 2693 | - |
dc.citation.publicationname | FASEB JOURNAL | - |
dc.identifier.doi | 10.1096/fj.201800431R | - |
dc.contributor.localauthor | Kim, Yoon Ki | - |
dc.contributor.nonIdAuthor | Ryu, Incheol | - |
dc.contributor.nonIdAuthor | Park, Yeonkyoung | - |
dc.contributor.nonIdAuthor | Seo, Jwa-Won | - |
dc.contributor.nonIdAuthor | Park, Ok Hyun | - |
dc.contributor.nonIdAuthor | Ha, Hongseok | - |
dc.contributor.nonIdAuthor | Nam, Jin-Wu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | mRNA stability | - |
dc.subject.keywordAuthor | 3UTR | - |
dc.subject.keywordAuthor | polyadenylation signal | - |
dc.subject.keywordAuthor | UVC | - |
dc.subject.keywordPlus | LOOP-BINDING-PROTEIN | - |
dc.subject.keywordPlus | ALTERNATIVE POLYADENYLATION | - |
dc.subject.keywordPlus | STEM-LOOP | - |
dc.subject.keywordPlus | RAPID DEGRADATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | INTERACTS | - |
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