Modeling Incorporating the Severity-Reducing Long-term Immunity: Higher Viral Transmission Paradoxically Reduces Severe COVID-19 During Endemic Transition

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Natural infection with severe acute respiratory syndrome-coronavirus-2 or vaccination induces virus-specific immunity protecting hosts from infection and severe disease. While the infection-preventing immunity gradually declines, the severity-reducing immunity is relatively well preserved. Here, based on the different longevity of these distinct immunities, we develop a mathematical model to estimate courses of endemic transition of coronavirus disease 2019 (COVID-19). Our analysis demonstrates that high viral transmission unexpectedly reduces the rates of progression to severe COVID-19 during the course of endemic transition despite increased numbers of infection cases. Our study also shows that high viral transmission amongst populations with high vaccination coverages paradoxically accelerates the endemic transition of COVID-19 with reduced numbers of severe cases. These results provide critical insights for driving public health policies in the era of 'living with COVID-19.'
Publisher
KOREA ASSOC IMMUNOLOGISTS
Issue Date
2022-06
Language
English
Article Type
Article
Citation

IMMUNE NETWORK, v.22, no.3

ISSN
1598-2629
DOI
10.4110/in.2022.22.e23
URI
http://hdl.handle.net/10203/297377
Appears in Collection
MA-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
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