The main sources of technological development are from abroad rather than domestic in many countries. The global networks for knowledge and technology flows are becoming sophisticated. This article examines how a country's embeddedness in the global knowledge spillover networks, particularly trade and FDI, is related to national innovation performance. Network closure and structural hole, the main arguments in network theory literature, represent the main objectives of our network analysis. The results are subsequently used to assess how these network characteristics are related to national innovation performance via panel negative binomial regression analysis. The findings show an overall tendency of a negative effect of network closure and a positive one of structural holes on a country's innovative outcome. In conclusion, this article not only highlights the significant role of network characteristics in national innovation performance, but also provides implications on how to leverage such network resources to improve national innovation systems.