The shuttling effect of lithium polysulfide (LiPS), which leads to the gravest capacity degradation, is one of the critical problems to hindering the commercialization of lithium-sulfur batteries (LSBs). Here, collectively exhaustive Ti3C2Tx MXene and graphene oxide (GO) multilayers are reported to suppress the shuttling effect by utilizing both physical inhibition of micro/mesoporous and chemical absorption of surface functional groups. The abundant surface functional groups of GO and MXene attract the positively charged lithium ion (Li+) and eject the negatively charged polysulfides (S-n(2-)) through electrostatic affinity and repulsion. A simple approach using vacuum filtration is utilized to encapsulate elemental sulfur (S-8) between GO and MXene film (GSM), acting as a permselective separator and functionalized current collector, respectively. The functionally antagonistic GSM directly plays a role in a cathode for LSBs and exhibits a specific capacity of 1425 mAh g(-1) at 0.1C in the initial cycle. The abundant functional groups, which can chemisorb the LiPSs, result in a high cyclic retention of approximate to 85.1% after 500 cycles. Furthermore, a flexible LSB is demonstrated with a PEO-LiTFSI electrolyte based on the flexibility of the exceptionally thin GSM due to the 2D nanomaterials, MXene and graphene oxide.