We introduce the notion of potentially klt pairs for normal projective varieties with pseudoeffective anticanonical divisor. The potentially non-klt locus is a subset of X which is birationally transformed precisely into the non-klt locus on a -K-X-minimal model of X. We prove basic properties of potentially non-klt locus in comparison with those of classical non-klt locus. As applications, we give a new characterization of varieties of Fano type, and we also improve results on the rational connectedness of uniruled varieties with pseudoeffective anticanonical divisor.