Due to the 4th industrial revolution and the strength of the 5(th) Generation (5G) era, the Internet of Things (IoT) industry is growing significantly. As a result, the number of IoT devices in various industries, such as smart cars, smart homes, and smart healthcare, and the importance of security for these devices are increasing. This study proposes a design method for a secure cryptographic system on a chip (SecSoC) that can be used in the IoT industry and presents the results of the performance and security evaluations of the implemented chipset. The experimental results demonstrated that the SecSoC is a low-power high-performance cryptographic chip that is safe from external attacks. Compared to conventional smart card integrated circuits, the proposed design includes intrusion detection circuits that can respond to external attacks. At the same time, it supports a physical unclonable function for hiding secret data and cryptographic logic for maintaining integrity and confidentiality. The SecSoC ensured a fast transfer rate up to 110 Mbps and consumed only 95.8 mW when operating at maximum frequency.