CRISPR/Cas12a collateral cleavage activity for an ultrasensitive assay of RNase H
We herein describe an ultrasensitive RNase H assay by utilizing CRISPR/Cas12a collateral cleavage activity. Based on this unique design principle, the RNase H activity was successfully determined down to 0.00024 U mL(-1), which is quite superior to those of alternative approaches.
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2022-02
- Language
- English
- Article Type
- Article
- Citation
CHEMICAL COMMUNICATIONS, v.58, no.16, pp.2654 - 2657
- ISSN
- 1359-7345
- Appears in Collection
- CBE-Journal Papers(저널논문)
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