Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery

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Coronary plaque destabilization involves alterations in microstructure and biochemical composition; however, no imaging approach allows such comprehensive characterization. Herein, the authors demonstrated a simultaneous microstructural and biochemical assessment of high-risk plaques in the coronary arteries in a beating heart using a fully integrated optical coherence tomography and fluorescence lifetime imaging (FLIm). It was found that plaque components such as lipids, macrophages, lipids+macrophages, and fibrotic tissues had unique fluorescence lifetime signatures that were distinguishable using multispectral FLIm. Because FLIm yielded massive biochemical readouts, the authors incorporated machine learning framework into FLIm, and ultimately, their approach enabled an automated, quantitative imaging of multiple key components relevant for plaque destabilization. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2021-12
Language
English
Article Type
Article
Citation

JACC-BASIC TO TRANSLATIONAL SCIENCE, v.6, no.12, pp.948 - 960

ISSN
2452-302X
DOI
10.1016/j.jacbts.2021.10.005
URI
http://hdl.handle.net/10203/291726
Appears in Collection
ME-Journal Papers(저널논문)
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