Active drug loading and release behaviors of fourfold channel flopped-ferritin variants

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Human ferritin has been heavily investigated as a protein-based drug deliver agent, due to its unique hollow cage structure for drug loading and an intrinsic tumor targeting function. However, facile strategies for high-level drug loading and controlled release have not been established, which hampered the use of ferritin as an in vivo delivery platform. We examined active drug uptake and release patterns of various flopped ferritin variants, which use fourfold channels as a route for drug uptake. A flopped channel pore structure was adjusted by diverse mutations around the helix-connecting loop of the channel. Active loading and release of anti-cancer drug doxorubicin for these ferritin variants were quantitatively monitored. Drug-loading ability and spontaneous release degree were both enhanced by channel flopping and a pore size increase. The results could lay a stepping stone for further understanding of drug loading via fourfold ferritin channels.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2021-12
Language
English
Article Type
Article
Citation

BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.42, no.12, pp.1666 - 1671

ISSN
0253-2964
DOI
10.1002/bkcs.12415
URI
http://hdl.handle.net/10203/290971
Appears in Collection
CH-Journal Papers(저널논문)
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