Activation or exhaustion of CD8(+) T cells in patients with COVID-19

Cited 1 time in webofscience Cited 0 time in scopus
  • Hit : 50
  • Download : 0
In addition to CD4(+) T cells and neutralizing antibodies, CD8(+) T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8(+) T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8(+) T cells is decreased. In addition, several studies have reported an upregulation of inhibitory immune checkpoint receptors, such as PD-1, and the expression of exhaustion-associated gene signatures in CD8(+) T cells from patients with COVID-19. However, whether CD8(+) T cells are truly exhausted during COVID-19 has been a controversial issue. In the present review, we summarize the current understanding of CD8(+) T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8(+) T cells in the context of activation and exhaustion. We also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8(+) T cells and discuss long-term SARS-CoV-2-specific CD8(+) T-cell memory.
Publisher
CHIN SOCIETY IMMUNOLOGY
Issue Date
2021-10
Language
English
Article Type
Review
Citation

CELLULAR & MOLECULAR IMMUNOLOGY, v.18, no.10, pp.2325 - 2333

ISSN
1672-7681
DOI
10.1038/s41423-021-00750-4
URI
http://hdl.handle.net/10203/288085
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 1 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0