DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seonghun | ko |
dc.contributor.author | Lee, Sul A. | ko |
dc.contributor.author | Yoon, Heakyung | ko |
dc.contributor.author | Kim, Myung Yoon | ko |
dc.contributor.author | Yoo, Jae-Kwang | ko |
dc.contributor.author | Ahn, So-Hee | ko |
dc.contributor.author | Park, Cheol Hyoung | ko |
dc.contributor.author | Park, Jimin | ko |
dc.contributor.author | Nam, Bo Young | ko |
dc.contributor.author | Park, Jung Tak | ko |
dc.contributor.author | Han, Seung Hyeok | ko |
dc.contributor.author | Kang, Shin-Wook | ko |
dc.contributor.author | Kim, Nam Hee | ko |
dc.contributor.author | Kim, Hyun Sil | ko |
dc.contributor.author | Han, Dawool | ko |
dc.contributor.author | Yook, Jong In | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.contributor.author | Yoo, Tae-Hyun | ko |
dc.date.accessioned | 2021-09-08T07:10:12Z | - |
dc.date.available | 2021-09-08T07:10:12Z | - |
dc.date.created | 2021-09-08 | - |
dc.date.created | 2021-09-08 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | KIDNEY INTERNATIONAL, v.100, no.3, pp.570 - 584 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | http://hdl.handle.net/10203/287666 | - |
dc.description.abstract | Ischemia-reperfusion injury is a major cause of acute kidney injury. Recent studies on the pathophysiology of ischemia-reperfusion-induced acute kidney injury showed that immunologic responses significantly affect kidney ischemia-reperfusion injury and repair. Nuclear factor (NF)-kappa B signaling, which controls cytokine production and cell survival, is significantly involved in ischemia-reperfusion-induced acute kidney injury, and its inhibition can ameliorate ischemic acute kidney injury. Using EXPLOR, a novel, optogenetically engineered exosome technology, we successfully delivered the exosomal super-repressor inhibitor of NF-kappa B (Exo-srI kappa B) into B6 wild type mice before/after kidney ischemia-reperfusion surgery, and compared outcomes with those of a control exosome (Exo-Naive)-injected group. Exo-srI kappa B treatment resulted in lower levels of serum blood urea nitrogen, creatinine, and neutrophil gelatinase-associated lipocalin in post-ischemic mice than in the Exo-Naive treatment group. Systemic delivery of Exo-srI kappa B decreased NF-kappa B activity in post-ischemic kidneys and reduced apoptosis. Post-ischemic kidneys showed decreased gene expression of pro-inflammatory cytokines and adhesion molecules with Exo-srI kappa B treatment as compared with the control. Intravital imaging confirmed the uptake of exosomes in neutrophils and macrophages. Exo-srI kappa B treatment also significantly affected post-ischemic kidney immune cell populations, lowering neutrophil, monocyte/macrophage, and T cell frequencies than those in the control. Thus, modulation of NF-kappa B signaling through exosomal delivery can be used as a novel therapeutic method for ischemia-reperfusion-induced acute kidney injury. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Exosome-based delivery of super-repressor I kappa B alpha ameliorates kidney ischemia-reperfusion injury | - |
dc.type | Article | - |
dc.identifier.wosid | 000687311900014 | - |
dc.identifier.scopusid | 2-s2.0-85111054445 | - |
dc.type.rims | ART | - |
dc.citation.volume | 100 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 570 | - |
dc.citation.endingpage | 584 | - |
dc.citation.publicationname | KIDNEY INTERNATIONAL | - |
dc.identifier.doi | 10.1016/j.kint.2021.04.039 | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Kim, Seonghun | - |
dc.contributor.nonIdAuthor | Lee, Sul A. | - |
dc.contributor.nonIdAuthor | Yoon, Heakyung | - |
dc.contributor.nonIdAuthor | Kim, Myung Yoon | - |
dc.contributor.nonIdAuthor | Yoo, Jae-Kwang | - |
dc.contributor.nonIdAuthor | Ahn, So-Hee | - |
dc.contributor.nonIdAuthor | Park, Cheol Hyoung | - |
dc.contributor.nonIdAuthor | Park, Jimin | - |
dc.contributor.nonIdAuthor | Nam, Bo Young | - |
dc.contributor.nonIdAuthor | Park, Jung Tak | - |
dc.contributor.nonIdAuthor | Han, Seung Hyeok | - |
dc.contributor.nonIdAuthor | Kang, Shin-Wook | - |
dc.contributor.nonIdAuthor | Kim, Nam Hee | - |
dc.contributor.nonIdAuthor | Kim, Hyun Sil | - |
dc.contributor.nonIdAuthor | Han, Dawool | - |
dc.contributor.nonIdAuthor | Yook, Jong In | - |
dc.contributor.nonIdAuthor | Yoo, Tae-Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | ischemia-reperfusion injury | - |
dc.subject.keywordAuthor | NF-kappa B signaling | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MYOCARDIAL INJURY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | CELLS | - |
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