Cancer Cell-Sticky Hydrogels to Target the Cell Membrane of Invading Glioblastomas

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Owing to their remarkable infiltrative traits, glioblastomas develop unclear tumor margins toward the brain, hampering the complete resection. Since the remaining invasive cells tend to have resistance to therapeutics and cause recurrence around the surgical voids, this has been a major challenge for glioblastoma treatment. Thus, we design a cancer cell-sticky hydrogel (CSH) that interacts with the glioblastoma cells to impede their invasive motility by modifying the cell membrane with active thiol-enriched interfaces. Highly reactive thiols at the cell surface can make the infiltrated cancer cells adhere to the hydrogel, resulting in increased cell adhesion and decreased motility. Cotreatment with the CSH and chemical inhibitors of the major proinvasive molecules, focal adhesion kinase and hyaluronic acid synthase, maximized the invasion-inhibitory effect. In addition, a significant decrease in tumor mass was achieved via CSH implantation in mouse models. Overall, our results highlight the use of the CSH to inhibit the aggressive invasion as a novel therapeutic strategy against glioblastoma.
Publisher
AMER CHEMICAL SOC
Issue Date
2021-07
Language
English
Article Type
Article
Citation

ACS APPLIED MATERIALS & INTERFACES, v.13, no.27, pp.31371 - 31378

ISSN
1944-8244
DOI
10.1021/acsami.1c00388
URI
http://hdl.handle.net/10203/286963
Appears in Collection
BiS-Journal Papers(저널논문)
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