In this study, the structural reliability of plate-stiffened prismatic pressure vessels was analyzed over time. A reliability analysis was performed using a time-dependent structural reliability method based on the response surface method (RSM). The plate-stiffened prismatic pressure vessel had a rectangular cross-section with repeated internal load-bearing structures. For the structural analysis, this repeated structure was modeled as a strip, and a structural reliability analysis was performed to identify changes in the reliability index when general corrosion and pitting corrosion occurred in the outer shell. Pitting corrosion was assumed to be randomly distributed on the outer shell, and the reliability index according to the degree of pit (DOP) and time was analyzed. Analysis results confirmed that the change in the reliability index was larger when pitting corrosion was applied compared with when only general corrosion was applied. Additionally, it was confirmed that above a certain DOP, the reliability index was affected.