MiT Family Transcriptional Factors in Immune Cell Functions

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The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2021-05
Language
English
Article Type
Review
Citation

MOLECULES AND CELLS, v.44, no.5, pp.342 - 355

ISSN
1016-8478
DOI
10.14348/molcells.2021.0067
URI
http://hdl.handle.net/10203/286021
Appears in Collection
MSE-Journal Papers(저널논문)
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