Biomimetic lipid Nanocomplexes incorporating STAT3-inhibiting peptides effectively infiltrate the lung barrier and ameliorate pulmonary fibrosis

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 48
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorKeum, Hyeongseopko
dc.contributor.authorKim, Jinjooko
dc.contributor.authorYoo, Dohyunko
dc.contributor.authorKim, Tae Wooko
dc.contributor.authorSeo, Changjinko
dc.contributor.authorKim, Dohyeonko
dc.contributor.authorJon, Sangyongko
dc.date.accessioned2021-06-03T02:10:18Z-
dc.date.available2021-06-03T02:10:18Z-
dc.date.created2021-06-01-
dc.date.created2021-06-01-
dc.date.issued2021-04-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v.332, pp.160 - 170-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10203/285493-
dc.description.abstractActivation of signal transducer and activator of transcription 3 (STAT3) under conditions of inflammation plays a crucial role in the pathogenesis of life-threatening pulmonary fibrosis (PF), initiating pro-fibrotic signaling following its phosphorylation. While there have been attempts to interfere with STAT3 activation and associated signaling as a strategy for ameliorating PF, potent inhibitors with minimal systemic toxicity have yet to be developed. Here, we assessed the in vitro and in vivo therapeutic effectiveness of a cell-permeable peptide inhibitor of STAT3 phosphorylation, designated APTstat3-9R, for ameliorating the indications of pulmonary fibrosis. Our results demonstrate that APTstat3-9R formulated with biomimetic disc-shaped lipid nanoparticles (DLNPs) markedly enhanced the penetration of pulmonary surfactant barrier and alleviated clinical symptoms of PF while causing negligible systemic cytotoxicity. Taken together, our findings suggest that biomimetic lipid nanoparticle-assisted pulmonary delivery of APTstat3-9R may be a feasible therapeutic option for PF in the clinic, and could be applied to treat other fibrotic diseases.-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.titleBiomimetic lipid Nanocomplexes incorporating STAT3-inhibiting peptides effectively infiltrate the lung barrier and ameliorate pulmonary fibrosis-
dc.typeArticle-
dc.identifier.wosid000646728500005-
dc.identifier.scopusid2-s2.0-85101521034-
dc.type.rimsART-
dc.citation.volume332-
dc.citation.beginningpage160-
dc.citation.endingpage170-
dc.citation.publicationnameJOURNAL OF CONTROLLED RELEASE-
dc.identifier.doi10.1016/j.jconrel.2021.02.022-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.nonIdAuthorKim, Tae Woo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorAptides-
dc.subject.keywordAuthorLipid nanoparticles-
dc.subject.keywordAuthorCell penetrating peptides-
dc.subject.keywordAuthorPulmonary delivery-
dc.subject.keywordAuthorPulmonary fibrosis-
dc.subject.keywordAuthorSignal transducer and activator of transcription-
dc.subject.keywordAuthor3 (STAT3)-
dc.subject.keywordPlusALANINE AMINOTRANSFERASE-
dc.subject.keywordPlusMAST-CELLS-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusSTAT3-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusCONTRIBUTES-
dc.subject.keywordPlusPRINCIPLES-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusINJURY-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0