Effects of cell type-specific Shank3 deletion on synaptic and behavioral phenotype in mice = 세포 특이적 Shank3 결손이 생쥐의 시냅스 기능과 행동에 미치는 영향 연구

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Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders and Phelan-McDermid syndrome. Although previous studies of various Shank3-mutant mice have revealed diverse roles of Shank3 in the regulation of synaptic, neuronal and brain functions, whether Shank3 expression in excitatory and inhibitory neurons differentially contributes to mouse phenotypes remains largely unclear. In the present study, we generated mice carrying Shank3 deletions (exons 14–16) restricted to glutamatergic (excitatory) or GABAergic (inhibitory) neurons and characterized their electrophysiological and behavioral phenotypes. These mice show differential changes in excitatory synaptic transmission in the medial prefrontal cortex and dorsolateral striatum as well as changes in behaviors, including social interaction and communication, repetitive behaviors, locomotion and anxiety-like behaviors, with Shank3 deletion in GABAergic neurons generally inducing stronger changes. Our results suggest that glutamatergic and GABAergic Shank3 (exons 14–16) deletions differentially influence synaptic transmission and behaviors in mice.
Advisors
Kim, Eunjoonresearcher김은준researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2020.2,[vii, 95 p. :]

Keywords

Autism▼aPhelan-McDermid syndrome▼aShank3▼astriatum▼amedial prefrontal cortex▼asocial interaction▼arepetitive behavior; 자폐증▼aPhelan-McDermid 증후군▼aShank3▼a선조체▼a내측전두엽피질▼a사회적 교류▼a반복행동

URI
http://hdl.handle.net/10203/284177
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909404&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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