Two-stage meta-analysis with nonparametric Bayesian functional regression : applications in environmental epidemiology = 비모수 베이지안 함수적 회귀모형을 활용한 두단계 메타분석 : 환경역학에의 응용applications in environmental epidemiology

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Two-stage meta-analysis has been popularly used in epidemiological studies in which an association between environmental exposure and health response is investigated analyzing time-series data collected for multiple locations. The first stage estimates the location-specific association between exposure and response controlling for various confounders, whereas the second stage pools the associations across locations. The second stage often incorporates location-specific predictors (i.e., meta-predictors) to explain the between-location heterogeneity in the association, and is called meta-regression. The existing meta-regression typically relies on parametric assumptions and does not accommodate functional meta-predictors and spatial dependency. Motivated by this limitation, our research proposes a nonparametric Bayesian multivariate meta-regression which incorporates functional meta-predictors and spatial dependency. A flexible functional meta-regression is formulated by jointly modeling the association parameters and the functional meta-predictors using Dirichlet process (DP) or local DP mixtures. The functional meta-predictors, while being jointly modeled with the association parameters, are represented parsimoniously by orthonormal basis coefficients obtained through the functional principal component analysis. The proposed models are applied to two motivating data: temperature-mortality study and study of suicide seasonality. A simulation study is conducted to compare the performances of the two proposed models and a parametric functional meta-regression.
Advisors
Chung, Yeonseungresearcher정연승researcher
Description
한국과학기술원 :수리과학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 수리과학과, 2020.2,[v, 50 p. :]

Keywords

Dirichlet process mixture▼aFunctional regression▼aLocal Dirichlet process▼aSpatial dependency; 디리슈레 프로세스 혼합 모형▼a함수 회귀모형▼a국소 디리슈레 프로세스▼a공간적 상관성

URI
http://hdl.handle.net/10203/283579
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=907850&flag=dissertation
Appears in Collection
MA-Theses_Ph.D.(박사논문)
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