Kinetic analysis of multivalent protein interaction and its application to protein assembly = 단백질 다중 결합의 운동역학적 분석과 단백질 조립체 형성 전략으로서의 응용

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protein nano-prisms.; Numerous interactions in nature employ multivalent binding, where multiple ligands on one entity bind to multiple receptors on another. The avidities resulted in multivalent presentation of a ligand are orders of magnitude stronger than those for the corresponding monovalent interaction. Thanks to these unique collective properties, multivalent interaction is extensively used strategy to achieve high selectivity and affinity in researching area as well as in nature. But the detailed mechanism of these multivalent interactions and specific rule of binding is not revealed. Chapter 1 provides current understandings of multivalent interaction that kinetically approaches to the behavior and covers recent strategies for designing supramolecular protein assembly. Chapter 2 describes the changes of kinetic values ($k_{on} and k_{off}$) upon valency change of the protein-peptide pairs having different binding chemistry. By employing these multivalent interaction to nano-assembly, chapter 3 introduces a strategy to fabricate monodisperse protein assemblies
Advisors
Jung, Yongwonresearcher정용원researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2020.2,[vi, 95 p. :]

Keywords

Multivalent interaction▼aAvidity▼aKinetics▼aProtein-peptide interaction▼aMonodisperse protein assembly; 다중 결합▼a강한 결합력▼a운동역학▼a단백질-펩타이드 결합▼a단일 단백질 조립체

URI
http://hdl.handle.net/10203/283461
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=901546&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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