1. studies on asymmetric total synthesis of rhodonoids C and D, 2. total synthesis of attenols A and B

Abstract

Although rhodonoids are made in nature through the same intermediates, they have different ee% values for each rhodonoid. Although all of the rhodonoids have been synthesized in previous papers, they have all been reported as racemic compounds and did not explain why the ee% value in nature is different. However, in the previous paper, the synthesis of rhodonoid D was made as minor product to the synthesis of rhodonoid C, and thus the synthesis of rhodonoid D as major product was successful. In addition, ee% value of the rhodonoid Along with the first successful asymmetric synthesis, we can get a clue to find out how the synthesis path in nature proceeds. Thus, when rhodnoids A, C, D, and G are produced, they start from the same compound. This precursor has been successfully synthesized using this catalyst, and the asymmetric synthesis of rhodonides C and D It was successful.

Attenol A and B are compounds separated from the shellfish called Pinna attenuate, each having a [5,6] -spiroketal, 6,8-DOBCO structure. In the past, many groups have successfully synthesized athenol A and B. However, these papers succeeded in obtaining atenol A and B as a mixture, or synthesizing only atenol A or B. However, since atenol A and B can be isomerized to each other and they will be synthesized in the same precursor in nature, it has been suggested that the synthesis is carried out in the nature of the progress of synthesis. The aim was to make atenol A and B through the cyclization reaction using the gold catalyst in the precursor having the gold catalyst.