Transgenic mouse capable of spatial and temporal control of expression and site-specific modification of target protein, production method and uses thereof목적 단백질의 위치 특이적 변형이 시공간적으로 조절되는 마우스, 이의 제조방법 및 그 용도

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The present invention relates to a mouse (Mus musculus) in which expression and site-specific modification of a target protein is temporally and spatially controlled, and a method for producing the same and the use thereof, and more particularly to a transgenic mouse in which expression of a target protein having a modification attached to a specific position is temporally and spatially controlled as a result of incorporation of an unnatural amino acid. In the mouse according to the present invention, in which site-specific modification of a target protein is temporally and spatially controllable, expression of the target protein having the site-specific modification attached thereto is controllable depending on the timing and/or position of introduction of an unnatural amino acid. Thus, the mouse according to the present invention is useful for studies on the in vivo functions of cellular proteins, various human diseases including cancers and neurodegenerative disorders, new drug discovery, and the like.
Assignee
KAIST
Country
US (United States)
Application Date
2017-09-05
Application Number
15695417
Registration Date
2021-02-02
Registration Number
10905107
URI
http://hdl.handle.net/10203/282439
Appears in Collection
CH-Patent(특허)
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