Hemostatic Needles: Controlling Hemostasis Time by a Catecholamine Oxidative Pathway

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Most infectious human viruses are generally found in the bloodstream after being released by infected organs. Thus, hemorrhage in patients, whose blood contains infectious viruses might be a significant risk for secondary infections. In this work, a self-sealing hemostatic needle that causes no bleeding even after its removal is reported. The materials used for the self-sealing needles are inspired by mussel adhesive polysaccharide, chitosan-catechol, which shows a rapid phase transition from a solid phase (i.e., a thin film) to an adhesive gel upon coming into contact with blood. We found that the self-sealing time for the complete hemostasis depends on the oxidation pathway of the conjugated catechol. For high-temperature oxidation (i.e., 60 degrees C), Michael addition is a dominant oxidative coupling reaction, which weakens the chitosan-catechol attachment force on the needle surface. Thus, the film is easily transferred to the hemorrhaging sites, with the result that there is no bleeding even after a short injection time (<5 s). In contrast, during low-temperature oxidation (4 degrees C), Schiff base formation is dominant, which strengthens the film attachment force on the needle surface, resulting in continued bleeding owing to a dearth of tissue transfer after the injection.
Publisher
AMER CHEMICAL SOC
Issue Date
2021-03
Language
English
Article Type
Article
Citation

ACS APPLIED MATERIALS &amp; INTERFACES, v.13, no.9, pp.10741 - 10747

ISSN
1944-8244
DOI
10.1021/acsami.0c22223
URI
http://hdl.handle.net/10203/282380
Appears in Collection
CH-Journal Papers(저널논문)
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