Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors

Cited 15 time in webofscience Cited 12 time in scopus
  • Hit : 669
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorKweon, Hanseulko
dc.contributor.authorJung, Won Beomko
dc.contributor.authorIm, Geun Hoko
dc.contributor.authorRyoo, Jiako
dc.contributor.authorLee, Joon-Hyukko
dc.contributor.authorDo, Hogyeongko
dc.contributor.authorChoi, Yeonsooko
dc.contributor.authorSong, You-Hyangko
dc.contributor.authorJung, Hwajinko
dc.contributor.authorPark, Haramko
dc.contributor.authorQiu, Lily R.ko
dc.contributor.authorEllegood, Jacobko
dc.contributor.authorShim, Hyun-Jiko
dc.contributor.authorYang, Estherko
dc.contributor.authorKim, Hyunko
dc.contributor.authorLerch, Jason P.ko
dc.contributor.authorLee, Seung-Heeko
dc.contributor.authorChung, Won-Sukko
dc.contributor.authorKim, Daesooko
dc.contributor.authorKim, Seong-Giko
dc.contributor.authorKim, Eunjoonko
dc.date.accessioned2021-03-23T00:30:21Z-
dc.date.available2021-03-23T00:30:21Z-
dc.date.created2021-03-22-
dc.date.created2021-03-22-
dc.date.created2021-03-22-
dc.date.issued2021-02-
dc.identifier.citationCELL REPORTS, v.34, no.8-
dc.identifier.issn2211-1247-
dc.identifier.urihttp://hdl.handle.net/10203/281755-
dc.description.abstractCHD8 (chromodomain helicase DNA-binding protein 8) is a chromatin remodeler associated with autism spectrum disorders. Homozygous Chd8 deletion in mice leads to embryonic lethality, making it difficult to assess whether CHD8 regulates brain development and whether CHD8 haploinsufficiency-related macrocephaly reflects normal CHD8 functions. Here, we report that homozygous conditional knockout of Chd8 restricted to neocortical glutamatergic neurons causes apoptosis-dependent near-complete elimination of neocortical structures, These mice, however, display normal survival and hyperactivity, anxiolytic-like behavior, and increased social interaction. They also show largely normal auditory function and moderately impaired visual and motor functions but enhanced whisker-related somatosensory function. These changes accompany thalamic hyperactivity, revealed by 15.2-Tesla fMRI, and increased intrinsic excitability and decreased inhibitory synaptic transmission in thalamic ventral posterior medial (VPM) neurons involved in somatosensation. These results suggest that excitatory neuronal CHD8 critically regulates neocortical development through anti-apoptotic mechanisms, neocortical elimination distinctly affects cognitive behaviors and sensory-motor functions in mice, and Chd8 haploinsufficiency-related macrocephaly might represent compensatory responses.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleExcitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors-
dc.typeArticle-
dc.identifier.wosid000621772300014-
dc.identifier.scopusid2-s2.0-85101073368-
dc.type.rimsART-
dc.citation.volume34-
dc.citation.issue8-
dc.citation.publicationnameCELL REPORTS-
dc.identifier.doi10.1016/j.celrep.2021.108780-
dc.contributor.localauthorLee, Seung-Hee-
dc.contributor.localauthorChung, Won-Suk-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.nonIdAuthorKweon, Hanseul-
dc.contributor.nonIdAuthorJung, Won Beom-
dc.contributor.nonIdAuthorIm, Geun Ho-
dc.contributor.nonIdAuthorDo, Hogyeong-
dc.contributor.nonIdAuthorChoi, Yeonsoo-
dc.contributor.nonIdAuthorJung, Hwajin-
dc.contributor.nonIdAuthorPark, Haram-
dc.contributor.nonIdAuthorQiu, Lily R.-
dc.contributor.nonIdAuthorEllegood, Jacob-
dc.contributor.nonIdAuthorShim, Hyun-Ji-
dc.contributor.nonIdAuthorYang, Esther-
dc.contributor.nonIdAuthorKim, Hyun-
dc.contributor.nonIdAuthorLerch, Jason P.-
dc.contributor.nonIdAuthorKim, Seong-Gi-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDE-NOVO MUTATIONS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusBARREL CORTEX-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusRECRUITMENT-
dc.subject.keywordPlusNETWORK-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 15 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0