Spread spectrum SERS allows label-free detection of attomolar neurotransmitters

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The quantitative label-free detection of neurotransmitters provides critical clues in understanding neurological functions or disorders. However, the identification of neurotransmitters remains challenging for surface-enhanced Raman spectroscopy (SERS) due to the presence of noise. Here, we report spread spectrum SERS (ss-SERS) detection for the rapid quantification of neurotransmitters at the attomolar level by encoding excited light and decoding SERS signals with peak autocorrelation and near-zero cross-correlation. Compared to conventional SERS measurements, the experimental result of ss-SERS shows an exceptional improvement in the signal-to-noise ratio of more than three orders of magnitude, thus achieving a high temporal resolution of over one hundred times. The ss-SERS measurement further allows the attomolar SERS detection of dopamine, serotonin, acetylcholine, γ-aminobutyric acid, and glutamate without Raman reporters. This approach opens up opportunities not only for investigating the early diagnostics of neurological disorders or highly sensitive biomedical SERS applications but also for developing low-cost spectroscopic biosensing applications. © 2021, The Author(s).
Publisher
NATURE RESEARCH
Issue Date
2021-01
Language
English
Article Type
Article
Citation

NATURE COMMUNICATIONS, v.12, no.1, pp.159

ISSN
2041-1723
DOI
10.1038/s41467-020-20413-8
URI
http://hdl.handle.net/10203/281740
Appears in Collection
BiS-Journal Papers(저널논문)
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