Label-free multimodal microscopy using a single light source and detector for biological imaging

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dc.contributor.authorKang, Juehyungko
dc.contributor.authorKang, Ungyoko
dc.contributor.authorNam, Hyeong Sooko
dc.contributor.authorKim, Wooseopko
dc.contributor.authorKim, Hyun Jungko
dc.contributor.authorKim, Ryeong Hyeonko
dc.contributor.authorKim, Jin Wonko
dc.contributor.authorYoo, Hongkiko
dc.date.accessioned2021-03-19T06:10:06Z-
dc.date.available2021-03-19T06:10:06Z-
dc.date.created2021-02-17-
dc.date.created2021-02-17-
dc.date.created2021-02-17-
dc.date.issued2021-02-
dc.identifier.citationOPTICS LETTERS, v.46, no.4, pp.892 - 895-
dc.identifier.issn0146-9592-
dc.identifier.urihttp://hdl.handle.net/10203/281704-
dc.description.abstractMultimodal nonlinear microscopy has been widely applied in biology and medicine due to its relatively deep penetration into tissue and its label-free manner. However, current multimodal systems require the use of multiple sources and detectors, leading to bulky, complex, and expensive systems. In this Letter, we present a novel method of using a single light source and detector for nonlinear multimodal imaging of biological samples. Using a photonic crystal fiber, a pulse picker, and multimode fibers, our developed system successfully acquired multimodal images of swine coronary arteries, including two-photon excitation fluorescence, second-harmonic generation, coherent anti-Stokes Raman scattering, and backreflection. The developed system could be a valuable tool for various biomedical applications.-
dc.languageEnglish-
dc.publisherOPTICAL SOC AMER-
dc.titleLabel-free multimodal microscopy using a single light source and detector for biological imaging-
dc.typeArticle-
dc.identifier.wosid000618473600049-
dc.identifier.scopusid2-s2.0-85101470855-
dc.type.rimsART-
dc.citation.volume46-
dc.citation.issue4-
dc.citation.beginningpage892-
dc.citation.endingpage895-
dc.citation.publicationnameOPTICS LETTERS-
dc.identifier.doi10.1364/ol.415938-
dc.contributor.localauthorYoo, Hongki-
dc.contributor.nonIdAuthorKang, Juehyung-
dc.contributor.nonIdAuthorKim, Wooseop-
dc.contributor.nonIdAuthorKim, Hyun Jung-
dc.contributor.nonIdAuthorKim, Ryeong Hyeon-
dc.contributor.nonIdAuthorKim, Jin Won-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlus2-PHOTON-
dc.subject.keywordPlusFLUORESCENCE-
dc.subject.keywordPlusHISTOLOGY-
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ME-Journal Papers(저널논문)
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