Label-free multimodal microscopy using a single light source and detector for biological imaging

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Multimodal nonlinear microscopy has been widely applied in biology and medicine due to its relatively deep penetration into tissue and its label-free manner. However, current multimodal systems require the use of multiple sources and detectors, leading to bulky, complex, and expensive systems. In this Letter, we present a novel method of using a single light source and detector for nonlinear multimodal imaging of biological samples. Using a photonic crystal fiber, a pulse picker, and multimode fibers, our developed system successfully acquired multimodal images of swine coronary arteries, including two-photon excitation fluorescence, second-harmonic generation, coherent anti-Stokes Raman scattering, and backreflection. The developed system could be a valuable tool for various biomedical applications.
Publisher
OPTICAL SOC AMER
Issue Date
2021-02
Language
English
Article Type
Article
Citation

OPTICS LETTERS, v.46, no.4, pp.892 - 895

ISSN
0146-9592
DOI
10.1364/ol.415938
URI
http://hdl.handle.net/10203/281704
Appears in Collection
ME-Journal Papers(저널논문)
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