DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hoang, Quan Truong | ko |
dc.contributor.author | Lee, DaeYong | ko |
dc.contributor.author | Choi, Dae Gun | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.contributor.author | Shim, Min Suk | ko |
dc.date.accessioned | 2021-03-11T02:50:06Z | - |
dc.date.available | 2021-03-11T02:50:06Z | - |
dc.date.created | 2021-03-11 | - |
dc.date.created | 2021-03-11 | - |
dc.date.created | 2021-03-11 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.95, pp.101 - 108 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/281464 | - |
dc.description.abstract | High levels of intracellular reactive oxygen species (ROS) in cancer cells have emerged as a cancer-specific stimulus that can be utilized for anticancer therapy. Therefore, ROS-responsive drug carriers have attracted considerable attention as cancer-specific drug delivery systems. In this study, an ROS-responsive poly(ethylene glycol)-poly(methionine) [PEG-P(Met)] was synthesized to achieve safe and effective delivery of piperlongumine (PL), a pro-oxidant drug, into cancer cells. Nanoscale core-shell micelles encapsulating hydrophobic PL into a P(Met) core were prepared by self-assembling. The increased ROS levels in cancer cells triggered a hydrophobic-to-hydrophilic transition of the polypeptide, which led to the ROS-responsive disassembly of the micelles and consequently efficient PL release into cancer cells. Compared to free PL, PL-loaded PEG-P(Met) [(PL-PEG-P(Met)] micelles exhibited enhanced apoptosis in MCF-7 human breast cancer cells owing to the efficient intracellular delivery of PL. Notably, the PL-PEG-P(Met) micelles exhibited cancer-specific cytotoxicity in MCF-7 human breast cancer cells owing to a considerable increase in intracellular ROS level in the cells. These results demonstrate that the ROS-responsive PEG-P(Met)-based micelles are safe and effective drug carriers for intracellular delivery of PL, which can provide cancer-selective pro-oxidant therapy. (c) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Efficient and selective cancer therapy using pro-oxidant drug-loaded reactive oxygen species (ROS)-responsive polypeptide micelles | - |
dc.type | Article | - |
dc.identifier.wosid | 000615937700011 | - |
dc.identifier.scopusid | 2-s2.0-85098667930 | - |
dc.type.rims | ART | - |
dc.citation.volume | 95 | - |
dc.citation.beginningpage | 101 | - |
dc.citation.endingpage | 108 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jiec.2020.12.009 | - |
dc.identifier.kciid | ART002699365 | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Hoang, Quan Truong | - |
dc.contributor.nonIdAuthor | Choi, Dae Gun | - |
dc.contributor.nonIdAuthor | Shim, Min Suk | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Poly(methionine) | - |
dc.subject.keywordAuthor | Piperlongumine | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Pro-oxidant therapy | - |
dc.subject.keywordAuthor | Cancer therapy | - |
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