튜머로이드-혈관신생 상호작용의 가시화를 위한 개방형 구조 미세유체 칩 개발Development of open-top microfluidic chip for visualization of interactions between tumoroids and angiogenic sprouting

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Cancer cells secrete angiogenic factors, and nearby vasculatures make new blood vessels essential for cancer development and metastasis in response to these soluble factors. Many efforts have been made to elucidate cancer-endothelial cell interactions in vitro. However, not much is known due to the lack of a suitable co-culture platform. Here, we introduce a 3D printing-based microfluidic system that mimics the in vivo-like cancer-endothelial cell interactions. The tumoroids and endothelial cells are co-cultured, physically separated by porous fibrin gel, allowing communication between two cell types through soluble factors. Using this microfluidic system, we were able to visualize new vessel formation induced by tumoroids of different origins, including liver, breast, and ovary. We confirmed that the ovarian tumoroids most induced angiogenesis while the other two cancer types suppressed it. Utilization of the proposed co-culture platform will help the researchers unveil the underlying mechanisms of the dynamic interplay between tumor and angiogenesis.
Publisher
한국가시화정보학회
Issue Date
2020-12
Language
Korean
Citation

한국가시화정보학회지, v.18, no.3, pp.1 - 6

ISSN
1598-8430
URI
http://hdl.handle.net/10203/281436
Appears in Collection
ME-Journal Papers(저널논문)
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