A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

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Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood–brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs. © 2021, The Author(s).
Publisher
Nature Publishing Group
Issue Date
2021-12
Language
English
Article Type
Article
Citation

Nature Communications, v.12, no.1, pp.280

ISSN
2041-1723
DOI
10.1038/s41467-020-20440-5
URI
http://hdl.handle.net/10203/281310
Appears in Collection
BiS-Journal Papers(저널논문)
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