DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sheller-Miller, Samantha | ko |
dc.contributor.author | Radnaa, Enkhtuya | ko |
dc.contributor.author | Yoo, Jae-Kwang | ko |
dc.contributor.author | Kim, Eunsoo | ko |
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Kim, Youngeun | ko |
dc.contributor.author | Kim, Yuna | ko |
dc.contributor.author | Richardson, Lauren | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.contributor.author | Menon, Ramkumar | ko |
dc.date.accessioned | 2021-03-02T08:50:05Z | - |
dc.date.available | 2021-03-02T08:50:05Z | - |
dc.date.created | 2021-02-23 | - |
dc.date.created | 2021-02-23 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | SCIENCE ADVANCES, v.7, no.4, pp.eabd3865 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/10203/281117 | - |
dc.description.abstract | Accumulation of immune cells and activation of the pro-inflammatory transcription factor NF-kappa B in feto-maternal uterine tissues is a key feature of preterm birth (PTB) pathophysiology. Reduction of the fetal inflammatory response and NF-kappa B activation are key strategies to minimize infection-associated PTB. Therefore, we engineered extracellular vesicles (exosomes) to contain an NF-kappa B inhibitor, termed super-repressor (SR) I kappa B alpha. Treatment with SR exosomes (1 x 10(10 )per intraperitoneal injection) after lipopolysaccharide (LPS) challenge on gestation day 15 (E15) prolonged gestation by over 24 hours (PTB <= E18.5) and reduced maternal inflammation (n >= 4). Furthermore, using a transgenic model in which fetal tissues express the red fluorescent protein tdTomato while maternal tissues do not, we report that LPS-induced PTB in mice is associated with influx of fetal innate immune cells, not maternal, into feto-maternal uterine tissues. SR packaged in exosomes provides a stable and specific intervention for reducing the inflammatory response associated with PTB. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Exosomal delivery of NF-kappa B inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models | - |
dc.type | Article | - |
dc.identifier.wosid | 000610099000018 | - |
dc.identifier.scopusid | 2-s2.0-85099903157 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | eabd3865 | - |
dc.citation.publicationname | SCIENCE ADVANCES | - |
dc.identifier.doi | 10.1126/sciadv.abd3865 | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Sheller-Miller, Samantha | - |
dc.contributor.nonIdAuthor | Radnaa, Enkhtuya | - |
dc.contributor.nonIdAuthor | Yoo, Jae-Kwang | - |
dc.contributor.nonIdAuthor | Kim, Eunsoo | - |
dc.contributor.nonIdAuthor | Choi, Kyungsun | - |
dc.contributor.nonIdAuthor | Kim, Youngeun | - |
dc.contributor.nonIdAuthor | Kim, Yuna | - |
dc.contributor.nonIdAuthor | Richardson, Lauren | - |
dc.contributor.nonIdAuthor | Menon, Ramkumar | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRANSFORMING-GROWTH-FACTOR | - |
dc.subject.keywordPlus | INTERLEUKIN-10 INHIBITION | - |
dc.subject.keywordPlus | THERAPEUTIC IMPLICATIONS | - |
dc.subject.keywordPlus | LABOR | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | CERVIX | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | PROSTAGLANDINS | - |
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