Thin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery

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dc.contributor.authorGoh, Keng Siangko
dc.contributor.authorChen, Yunfengko
dc.contributor.authorChong, Jeng Yiko
dc.contributor.authorBae, Tae Hyunko
dc.contributor.authorWang, Rongko
dc.date.accessioned2021-02-26T06:50:04Z-
dc.date.available2021-02-26T06:50:04Z-
dc.date.created2021-02-18-
dc.date.created2021-02-18-
dc.date.issued2021-03-
dc.identifier.citationJOURNAL OF MEMBRANE SCIENCE, v.621, pp.119008-
dc.identifier.issn0376-7388-
dc.identifier.urihttp://hdl.handle.net/10203/281050-
dc.description.abstractA 100-piece hollow fibre thin-film composite membrane module was successfully developed for pharmaceutical concentration and solvent recovery. To increase its packing density, thinner P84 polyimide hollow fibre substrates were spun using a smaller spinneret. The substrates were subsequently cross-linked with hexamethylene diamine to achieve organic solvent resistance. An MPD-based thin-film composite was synthesized through interfacial polymerisation to increase selectivity for solutes of less than 300 Da. The thin-film composite was then solvent-activated using N,N-dimethylformamide to increase its solvent permeability. The resulting membrane exhibited excellent performance with 24.2 m(-2) h(-1) bar(-1) acetone permeability and 90.1% methyl red (269 Da) rejection. In addition, the solvent-activated membrane maintained its performance for prolonged period, demonstrating the scalability of the thin-film composite fabrication process and stability of solvent-activated membranes. The membrane was also able to concentrate levofloxacin (361 Da) from 500 ppm to 20,000 ppm in acetone using a batch process, showing promising results for pharmaceutical applications.-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.titleThin film composite hollow fibre membrane for pharmaceutical concentration and solvent recovery-
dc.typeArticle-
dc.identifier.wosid000609148300001-
dc.identifier.scopusid2-s2.0-85098528436-
dc.type.rimsART-
dc.citation.volume621-
dc.citation.beginningpage119008-
dc.citation.publicationnameJOURNAL OF MEMBRANE SCIENCE-
dc.identifier.doi10.1016/j.memsci.2020.119008-
dc.contributor.localauthorBae, Tae Hyun-
dc.contributor.nonIdAuthorGoh, Keng Siang-
dc.contributor.nonIdAuthorChen, Yunfeng-
dc.contributor.nonIdAuthorChong, Jeng Yi-
dc.contributor.nonIdAuthorWang, Rong-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorOrganic solvent nanofiltration-
dc.subject.keywordAuthorThin-film composite membrane module-
dc.subject.keywordAuthorOrganic solvent-
dc.subject.keywordAuthorResistance-
dc.subject.keywordAuthorSolvent recovery-
dc.subject.keywordPlusNANOFILTRATION (OSN)-INTERFACIAL POLYMERIZATION-
dc.subject.keywordPlusRESISTANT NANOFILTRATION-
dc.subject.keywordPlusSURFACE MODIFICATION-
dc.subject.keywordPlusPOLYIMIDE MEMBRANES-
dc.subject.keywordPlusP84 POLYIMIDE-
dc.subject.keywordPlusPERFORMANCE-
dc.subject.keywordPlusULTRAFILTRATION-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordPlusSEPARATION-
dc.subject.keywordPlusOSMOSIS-
Appears in Collection
CBE-Journal Papers(저널논문)
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