Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal-Free and Metal-Associated Amyloid-beta

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Aggregates of both metal-free amyloid-beta (A beta) and metal-bound A beta (metal-A beta) are accumulated in the brain affected by Alzheimer's disease. To control metal-free and metal-bound A beta species, chemical reagents capable of modulating their aggregation profiles have been developed. As an effort, the reactivity of natural products such as flavonoids with metal-free A beta and metal-A beta has been investigated to identify their use as chemical reagents and structural features essential for such reactivity. This review illustrates the effects of flavonoids containing a catechol or pyrogallol group on metal-free and metal-mediated A beta aggregation pathways. In addition, the studies regarding the structure-activity relationship of flavonoids against metal-free A beta or metal-A beta are discussed.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2021-01
Language
English
Article Type
Review; Early Access
Citation

BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.42, no.1, pp.17 - 24

ISSN
0253-2964
DOI
10.1002/bkcs.12172
URI
http://hdl.handle.net/10203/280423
Appears in Collection
CH-Journal Papers(저널논문)
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