DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nirschl, Christopher J. | ko |
dc.contributor.author | Suarez-Farinas, Mayte | ko |
dc.contributor.author | Izar, Benjamin | ko |
dc.contributor.author | Prakadan, Sanjay | ko |
dc.contributor.author | Dannenfelser, Ruth | ko |
dc.contributor.author | Tirosh, Itay | ko |
dc.contributor.author | Liu, Yong | ko |
dc.contributor.author | Zhu, Qian | ko |
dc.contributor.author | Devi, K. Sanjana P. | ko |
dc.contributor.author | Carroll, Shaina L. | ko |
dc.contributor.author | Chau, David | ko |
dc.contributor.author | Rezaee, Melika | ko |
dc.contributor.author | Kim, Tae-Gyun | ko |
dc.contributor.author | Huang, Ruiqi | ko |
dc.contributor.author | Fuentes-Duculan, Judilyn | ko |
dc.contributor.author | Song-Zhao, George X. | ko |
dc.contributor.author | Gulati, Nicholas | ko |
dc.contributor.author | Lowes, Michelle A. | ko |
dc.contributor.author | King, Sandra L. | ko |
dc.contributor.author | Quintana, Francisco J. | ko |
dc.contributor.author | Lee, Young-suk | ko |
dc.contributor.author | Krueger, James G. | ko |
dc.contributor.author | Sarin, Kavita Y. | ko |
dc.contributor.author | Yoon, Charles H. | ko |
dc.contributor.author | Garraway, Levi | ko |
dc.contributor.author | Regev, Aviv | ko |
dc.contributor.author | Shalek, Alex K. | ko |
dc.contributor.author | Troyanskaya, Olga | ko |
dc.contributor.author | Anandasabapathy, Niroshana | ko |
dc.date.accessioned | 2021-02-01T01:10:26Z | - |
dc.date.available | 2021-02-01T01:10:26Z | - |
dc.date.created | 2021-02-01 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | CELL, v.170, no.1, pp.127 - + | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/280419 | - |
dc.description.abstract | Homeostatic programs balance immune protection and self-tolerance. Such mechanisms likely impact autoimmunity and tumor formation, respectively. How homeostasis is maintained and impacts tumor surveillance is unknown. Here, we find that different immune mononuclear phagocytes share a conserved steady-state program during differentiation and entry into healthy tissue. IFN gamma is necessary and sufficient to induce this program, revealing a key instructive role. Remarkably, homeostatic and IFN gamma-dependent programs enrich across primary human tumors, including melanoma, and stratify survival. Single-cell RNA sequencing (RNA-seq) reveals enrichment of homeostatic modules in monocytes and DCs from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFN gamma. SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regulatory role. These findings link immune homeostasis to key determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumor microenvironment. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | IFN gamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment | - |
dc.type | Article | - |
dc.identifier.wosid | 000404358500015 | - |
dc.identifier.scopusid | 2-s2.0-85021662906 | - |
dc.type.rims | ART | - |
dc.citation.volume | 170 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 127 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/j.cell.2017.06.016 | - |
dc.contributor.localauthor | Lee, Young-suk | - |
dc.contributor.nonIdAuthor | Nirschl, Christopher J. | - |
dc.contributor.nonIdAuthor | Suarez-Farinas, Mayte | - |
dc.contributor.nonIdAuthor | Izar, Benjamin | - |
dc.contributor.nonIdAuthor | Prakadan, Sanjay | - |
dc.contributor.nonIdAuthor | Dannenfelser, Ruth | - |
dc.contributor.nonIdAuthor | Tirosh, Itay | - |
dc.contributor.nonIdAuthor | Liu, Yong | - |
dc.contributor.nonIdAuthor | Zhu, Qian | - |
dc.contributor.nonIdAuthor | Devi, K. Sanjana P. | - |
dc.contributor.nonIdAuthor | Carroll, Shaina L. | - |
dc.contributor.nonIdAuthor | Chau, David | - |
dc.contributor.nonIdAuthor | Rezaee, Melika | - |
dc.contributor.nonIdAuthor | Kim, Tae-Gyun | - |
dc.contributor.nonIdAuthor | Huang, Ruiqi | - |
dc.contributor.nonIdAuthor | Fuentes-Duculan, Judilyn | - |
dc.contributor.nonIdAuthor | Song-Zhao, George X. | - |
dc.contributor.nonIdAuthor | Gulati, Nicholas | - |
dc.contributor.nonIdAuthor | Lowes, Michelle A. | - |
dc.contributor.nonIdAuthor | King, Sandra L. | - |
dc.contributor.nonIdAuthor | Quintana, Francisco J. | - |
dc.contributor.nonIdAuthor | Krueger, James G. | - |
dc.contributor.nonIdAuthor | Sarin, Kavita Y. | - |
dc.contributor.nonIdAuthor | Yoon, Charles H. | - |
dc.contributor.nonIdAuthor | Garraway, Levi | - |
dc.contributor.nonIdAuthor | Regev, Aviv | - |
dc.contributor.nonIdAuthor | Shalek, Alex K. | - |
dc.contributor.nonIdAuthor | Troyanskaya, Olga | - |
dc.contributor.nonIdAuthor | Anandasabapathy, Niroshana | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MIGRATORY DENDRITIC CELLS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | FUNCTIONAL SPECIALIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESIDENT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXPLORATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
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