Liquid-Flowing Graphene Chip-Based High-Resolution Electron Microscopy

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The recent advances in liquid-phase transmission electron microscopy represent tremendous potential in many different fields and exciting new opportunities. However, achieving both high-resolution imaging and operando capabilities remain a significant challenge. This work suggests a novel in situ imaging platform of liquid-flowing graphene chip TEM (LFGC-TEM) equipped with graphene viewing windows and a liquid exchange system. The LFGCs are robust under high-pressure gradients and rapid liquid circulation in ranges covering the experimental conditions accessible with conventional thick SiNx chips. LFGC-TEM provides atomic resolution for colloidal nanoparticles and molecular-level information limits for unstained wet biomolecules and cells that are comparable to the resolutions achievable with solid-phase and cryogenic TEM, respectively. This imaging platform can provide an opportunity for live imaging of biological phenomena that is not yet achieved using any current methods.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2021-01
Language
English
Article Type
Article
Citation

ADVANCED MATERIALS, v.33, no.2, pp.2005468

ISSN
0935-9648
DOI
10.1002/adma.202005468
URI
http://hdl.handle.net/10203/280389
Appears in Collection
MS-Journal Papers(저널논문)
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