System-level understanding of gene expression and regulation for engineering secondary metabolite production inStreptomyces

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dc.contributor.authorLee, Yongjaeko
dc.contributor.authorLee, Namilko
dc.contributor.authorHwang, Soonkyuko
dc.contributor.authorKim, Kangsanko
dc.contributor.authorKim, Wooriko
dc.contributor.authorKim, Jihunko
dc.contributor.authorCho, Suhyungko
dc.contributor.authorPalsson, Bernhard O.ko
dc.contributor.authorCho, Byung-Kwanko
dc.date.accessioned2021-01-05T16:30:14Z-
dc.date.available2021-01-05T16:30:14Z-
dc.date.created2020-08-31-
dc.date.created2020-08-31-
dc.date.created2020-08-31-
dc.date.issued2020-10-
dc.identifier.citationJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.47, no.9-10, pp.739 - 752-
dc.identifier.issn1367-5435-
dc.identifier.urihttp://hdl.handle.net/10203/279554-
dc.description.abstractThe gram-positive bacterium,Streptomyces, is noticed for its ability to produce a wide array of pharmaceutically active compounds through secondary metabolism. To discover novel bioactive secondary metabolites and increase the production,Streptomycesspecies have been extensively studied for the past decades. Among the cellular components, RNA molecules play important roles as the messengers for gene expression and diverse regulations taking place at the RNA level. Thus, the analysis of RNA-level regulation is critical to understanding the regulation ofStreptomyces' metabolism and secondary metabolite production. A dramatic advance inStreptomycesresearch was made recently, by exploiting high-throughput technology to systematically understand RNA levels. In this review, we describe the current status of the system-wide investigation ofStreptomycesin terms of RNA, toward expansion of its genetic potential for secondary metabolite synthesis.-
dc.languageEnglish-
dc.publisherSPRINGER HEIDELBERG-
dc.titleSystem-level understanding of gene expression and regulation for engineering secondary metabolite production inStreptomyces-
dc.typeArticle-
dc.identifier.wosid000558105400001-
dc.identifier.scopusid2-s2.0-85089248910-
dc.type.rimsART-
dc.citation.volume47-
dc.citation.issue9-10-
dc.citation.beginningpage739-
dc.citation.endingpage752-
dc.citation.publicationnameJOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY-
dc.identifier.doi10.1007/s10295-020-02298-0-
dc.contributor.localauthorCho, Byung-Kwan-
dc.contributor.nonIdAuthorKim, Jihun-
dc.contributor.nonIdAuthorPalsson, Bernhard O.-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthorStreptomyces-
dc.subject.keywordAuthorSecondary metabolite-
dc.subject.keywordAuthorRNA-
dc.subject.keywordAuthorTranscription-
dc.subject.keywordAuthorTranslation-
dc.subject.keywordPlusTRANSCRIPTION UNIT ARCHITECTURE-
dc.subject.keywordPlusSTREPTOMYCES-COELICOLOR A3(2)-
dc.subject.keywordPlusLEADERLESS MESSENGER-RNAS-
dc.subject.keywordPlusCOMPLETE GENOME SEQUENCE-
dc.subject.keywordPlusANTIBIOTIC PRODUCTION-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusMORPHOLOGICAL DEVELOPMENT-
dc.subject.keywordPlusDRIVEN DISCOVERY-
dc.subject.keywordPlusWILD-TYPE-
dc.subject.keywordPlusPROTEIN-
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