Biosensor and Chemosensor Fluorophores that contain Chalcogenide Centers

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 111
  • Download : 21
In this timely review, we discuss the important attributes of various chalcogen-containing small-molecule probes that have been synthesized in the Molecular Logic Gate Laboratory at the Korea Advanced Institute of Science and Technology. Specifically, we discuss some of the important chemical and photophysical properties of these probes, including reversibility, responsiveness (response time), cellular localization, sensitivity to analytes, selectivity (toward a specific analyte in question), and some bioavailability criteria. Chalcogenides undergo reversible redox-type reactions with reactive oxygen species (ROS). These controlled solution reactions enable a sensible and clear response as they act to immediately affect the chemical and electronic properties of the chalcogen moiety. Often, the lone pair belongs to chalcogens, which communicate electronically with the rest of the probes. Importantly, chemically oxidized chalcogenides can revert to their original reduced (divalent) form through the addition of natural or unnatural biothiols (or other reductants). This phenomenon is considered reversibility from the standpoint of probes. It can also be called "resetability." In this manner, a variety of fluorophore frameworks can be used to detect ROS and thiols. Further studies can help experimentally determine the lipophilicity and even the cellular localization of probes, which are important in assessing their value as diagnostic agents in biological sciences and their possible therapeutic potential.
Publisher
UNIV INDONESIA
Issue Date
2020-06
Language
English
Article Type
Review
Citation

MAKARA JOURNAL OF SCIENCE, v.24, no.2, pp.119 - 134

ISSN
2339-1995
DOI
10.7454/mss.v24i1.12107
URI
http://hdl.handle.net/10203/279313
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
117463.pdf(2 MB)Download

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0