DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ku, Jayoung | ko |
dc.contributor.author | Kim, Ryul | ko |
dc.contributor.author | Kim, Dongchan | ko |
dc.contributor.author | Kim, Daeyoon | ko |
dc.contributor.author | Song, Seulki | ko |
dc.contributor.author | Lee, Keonyong | ko |
dc.contributor.author | Lee, Namseok | ko |
dc.contributor.author | Kim, MinA | ko |
dc.contributor.author | Yoon, Sung-Soo | ko |
dc.contributor.author | Kwon, Nam Hoon | ko |
dc.contributor.author | Kim, Sunghoon | ko |
dc.contributor.author | Koh, Youngil | ko |
dc.contributor.author | Kim, Yoosik | ko |
dc.date.accessioned | 2020-12-02T01:10:16Z | - |
dc.date.available | 2020-12-02T01:10:16Z | - |
dc.date.created | 2020-11-30 | - |
dc.date.issued | 2020-10-05 | - |
dc.identifier.citation | 2020 International Conference: Korean Society for Molecular and Cellular Biology, pp.278 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277901 | - |
dc.description.abstract | Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity and is associated with carcinogenesis, its clinical potential awaits further validation. Here, we found that AIMP2-DX2/AIMP2 expression ratio is strongly correlated with major cancer signaling pathways and poor prognosis, particularly in acute myeloid leukemia (AML). Analysis of a clinical patient cohort revealed that AIMP2-DX2 positive AML patients show decreased overall survival and progression-free survival. We also developed targeted RNA-sequencing and RNA-smFISH tools to quantitatively analyze AIMP2-DX2/AIMP2 ratios at the single-cell level. By subclassifying hematologic cancer cells based on their AIMP2-DX2/AIMP2 ratios, we found that downregulating AIMP2-DX2 sensitizes cells to anti-cancer drugs only for a subgroup of cells while it has adverse effects on others. Collectively, our study establishes AIMP2-DX2 as a potential biomarker and a therapeutic target for hematologic cancer. | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | Single-cell Analysis of Alternative Splicing Variant of AIMP2 and Its Clinical Implications in Hematologic Cancer | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.beginningpage | 278 | - |
dc.citation.endingpage | 278 | - |
dc.citation.publicationname | 2020 International Conference: Korean Society for Molecular and Cellular Biology | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | Virtual | - |
dc.contributor.localauthor | Kim, Yoosik | - |
dc.contributor.nonIdAuthor | Kim, Ryul | - |
dc.contributor.nonIdAuthor | Kim, Dongchan | - |
dc.contributor.nonIdAuthor | Kim, Daeyoon | - |
dc.contributor.nonIdAuthor | Song, Seulki | - |
dc.contributor.nonIdAuthor | Lee, Keonyong | - |
dc.contributor.nonIdAuthor | Lee, Namseok | - |
dc.contributor.nonIdAuthor | Kim, MinA | - |
dc.contributor.nonIdAuthor | Yoon, Sung-Soo | - |
dc.contributor.nonIdAuthor | Kwon, Nam Hoon | - |
dc.contributor.nonIdAuthor | Kim, Sunghoon | - |
dc.contributor.nonIdAuthor | Koh, Youngil | - |
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