DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hanseul | ko |
dc.contributor.author | Adam, Rene C. | ko |
dc.contributor.author | Ge, Yejing | ko |
dc.contributor.author | Hua, Zhong L. | ko |
dc.contributor.author | Fuchs, Elaine | ko |
dc.date.accessioned | 2020-11-17T02:55:12Z | - |
dc.date.available | 2020-11-17T02:55:12Z | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | CELL, v.169, no.3, pp.483 - + | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277328 | - |
dc.description.abstract | Adult tissue stem cells (SCs) reside in niches, which, through intercellular contacts and signaling, influence SC behavior. Once activated, SCs typically give rise to short-lived transit-amplifying cells (TACs), which then progress to differentiate into their lineages. Here, using single-cell RNA-seq, we unearth unexpected heterogeneity among SCs and TACs of hair follicles. We trace the roots of this heterogeneity to micro-niches along epithelial-mesenchymal interfaces, where progenitors display molecular signatures reflective of spatially distinct local signals and intercellular interactions. Using lineage tracing, temporal single-cell analyses, and chromatin landscaping, we show that SC plasticity becomes restricted in a sequentially and spatially choreographed program, culminating in seven spatially arranged unilineage progenitors within TACs of mature follicles. By compartmentalizing SCs into microniches, tissues gain precise control over morphogenesis and regeneration: some progenitors specify lineages immediately, whereas others retain potency, preserving self-renewing features established early while progressively restricting lineages as they experience dynamic changes in microenvironment. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices | - |
dc.type | Article | - |
dc.identifier.wosid | 000399560600012 | - |
dc.identifier.scopusid | 2-s2.0-85017423588 | - |
dc.type.rims | ART | - |
dc.citation.volume | 169 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 483 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/j.cell.2017.03.038 | - |
dc.contributor.localauthor | Yang, Hanseul | - |
dc.contributor.nonIdAuthor | Adam, Rene C. | - |
dc.contributor.nonIdAuthor | Ge, Yejing | - |
dc.contributor.nonIdAuthor | Hua, Zhong L. | - |
dc.contributor.nonIdAuthor | Fuchs, Elaine | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HAIR FOLLICLE RENEWAL | - |
dc.subject.keywordPlus | EXPRESSION ANALYSIS | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | COMMITMENT | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | DYNAMICS | - |
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