DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Yoonji | ko |
dc.contributor.author | Kwon, Sujeong | ko |
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | Lee, Dongyeop | ko |
dc.contributor.author | Park, Hae-Eun H. | ko |
dc.contributor.author | Yamaoka, Yasuyo | ko |
dc.contributor.author | Jeong, Dae-Eun | ko |
dc.contributor.author | Artan, Murat | ko |
dc.contributor.author | Altintas, Ozlem | ko |
dc.contributor.author | Park, Sangsoon | ko |
dc.contributor.author | Hwang, Wooseon | ko |
dc.contributor.author | Lee, Yujin | ko |
dc.contributor.author | Son, Heehwa G. | ko |
dc.contributor.author | An, Seon Woo A. | ko |
dc.contributor.author | Kim, Eun Ji E. | ko |
dc.contributor.author | Seo, Mihwa | ko |
dc.contributor.author | Lee, Seung-Jae, V | ko |
dc.date.accessioned | 2020-11-10T08:55:18Z | - |
dc.date.available | 2020-11-10T08:55:18Z | - |
dc.date.created | 2020-06-15 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | AGING CELL, v.19, no.6 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277192 | - |
dc.description.abstract | Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN-1, a phosphatidic acid phosphatase and a putative transcriptional coregulator, prevents life-shortening effects of dietary glucose on Caenorhabditis elegans. We found that depletion of lpin-1 decreased overall lipid levels, despite increasing the expression of genes that promote fat synthesis and desaturation, and downregulation of lipolysis. We then showed that knockdown of lpin-1 altered the composition of various fatty acids in the opposite direction of dietary glucose. In particular, the levels of two omega-6 polyunsaturated fatty acids (PUFAs), linoleic acid and arachidonic acid, were increased by knockdown of lpin-1 but decreased by glucose feeding. Importantly, these omega-6 PUFAs attenuated the short lifespan of glucose-fed lpin-1-inhibited animals. Thus, the production of omega-6 PUFAs is crucial for protecting animals from living very short under glucose-rich conditions. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Caenorhabditis elegans Lipin 1 moderates the lifespan-shortening effects of dietary glucose by maintaining omega-6 polyunsaturated fatty acids | - |
dc.type | Article | - |
dc.identifier.wosid | 000536390800001 | - |
dc.identifier.scopusid | 2-s2.0-85085612293 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | AGING CELL | - |
dc.identifier.doi | 10.1111/acel.13150 | - |
dc.contributor.localauthor | Lee, Seung-Jae, V | - |
dc.contributor.nonIdAuthor | Ham, Seokjin | - |
dc.contributor.nonIdAuthor | Lee, Dongyeop | - |
dc.contributor.nonIdAuthor | Park, Hae-Eun H. | - |
dc.contributor.nonIdAuthor | Yamaoka, Yasuyo | - |
dc.contributor.nonIdAuthor | Jeong, Dae-Eun | - |
dc.contributor.nonIdAuthor | Artan, Murat | - |
dc.contributor.nonIdAuthor | Altintas, Ozlem | - |
dc.contributor.nonIdAuthor | Park, Sangsoon | - |
dc.contributor.nonIdAuthor | Hwang, Wooseon | - |
dc.contributor.nonIdAuthor | Lee, Yujin | - |
dc.contributor.nonIdAuthor | Son, Heehwa G. | - |
dc.contributor.nonIdAuthor | An, Seon Woo A. | - |
dc.contributor.nonIdAuthor | Seo, Mihwa | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | glucose | - |
dc.subject.keywordAuthor | LPIN-1 | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordAuthor | omega-6 polyunsaturated fatty acids | - |
dc.subject.keywordPlus | C. ELEGANS | - |
dc.subject.keywordPlus | MEDIATOR SUBUNIT | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | LIPODYSTROPHY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MDT-15 | - |
dc.subject.keywordPlus | SREBP | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | MUTATION | - |
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