Thermoplasmonic Optical Fiber for Localized Neural Stimulation

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Thermoplasmonic effect-based neural stimulation has been suggested as an alternative optical neural stimulation technology without genetic modification. Integration of near-infrared light with plasmonic gold nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test the validity of the thermoplasmonic neural stimulation across multiple biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in optical neuromodulation, versatile engineering approaches to apply the thermoplasmonic effect would be required. In this work, we developed a gold nanorod attached optical fiber technology for the localized neural stimulation based on a thermoplasmonic effect. A simple fabrication process was developed for efficient nanoparticle coating on commercial optical fibers. The thermoplasmonic optical fiber proved that it can locally modulate the neural activity in vitro. Lastly, we simulated the spatiotemporal temperature change by the thermoplasmonic optical fiber and analyzed its applicability to in vivo animal models.
Publisher
AMER CHEMICAL SOC
Issue Date
2020-09
Language
English
Article Type
Article
Citation

ACS NANO, v.14, no.9, pp.11406 - 11419

ISSN
1936-0851
DOI
10.1021/acsnano.0c03703
URI
http://hdl.handle.net/10203/277078
Appears in Collection
BiS-Journal Papers(저널논문)
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