Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

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Micro-optical coherence tomography (mu OCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic mu OCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic mu OCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 mu m and 3.38 mu m in air, respectively. Furthermore, the depth of focus of the mu OCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic mu OCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic mu OCT will be a useful tool for investigating coronary artery disease and stent biology.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2020-06
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.10, no.1, pp.9248

ISSN
2045-2322
DOI
10.1038/s41598-020-65742-2
URI
http://hdl.handle.net/10203/275725
Appears in Collection
ME-Journal Papers(저널논문)
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