DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Byeong-Min | ko |
dc.contributor.author | Baek, Jong-In | ko |
dc.contributor.author | Kim, Min-Sung | ko |
dc.contributor.author | Kim, Sun-Chang | ko |
dc.contributor.author | Cui, Chang-hao | ko |
dc.date.accessioned | 2020-07-18T00:57:40Z | - |
dc.date.available | 2020-07-18T00:57:40Z | - |
dc.date.created | 2020-07-10 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | BIOMOLECULES, v.10, no.4 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | http://hdl.handle.net/10203/275514 | - |
dc.description.abstract | Background: Ginsenosides, triterpene saponins of Panax species, are considered the main active ingredients responsible for various pharmacological activities. Herein, a new protopanaxatriol-type ginsenoside called "ginsenoside MT1" is described; it was accidentally found among the enzymatic conversion products of ginsenoside Re. Method: We analyzed the conversion mechanism and found that recombinant beta-glucosidase (MT619) transglycosylated the outer rhamnopyranoside of Re at the C-6 position to glucopyranoside at C-20. The production of MT1 by trans-rhamnosylation was optimized and pure MT1 was obtained through various chromatographic processes. Results: The structure of MT1 was elucidated based on spectral data: (20S)-3 beta,6 alpha,12 beta,20-tetrahydroxydammarene-20-O-[alpha-L-rhamnopyranosyl(1 -> 2)-beta-D-glucopyranoside]. This dammarane-type triterpene saponin was confirmed as a novel compound. Conclusion: Based on the functions of ginsenosides with similar structures, we believe that this ginsenoside MT1 may have great potential in the development of nutraceutical, pharmaceutical or cosmeceutical products. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Characterization of a Novel Ginsenoside MT1 Produced by an Enzymatic Transrhamnosylation of Protopanaxatriol-Type Ginsenosides Re | - |
dc.type | Article | - |
dc.identifier.wosid | 000539492400031 | - |
dc.identifier.scopusid | 2-s2.0-85083041685 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | BIOMOLECULES | - |
dc.identifier.doi | 10.3390/biom10040525 | - |
dc.contributor.localauthor | Kim, Sun-Chang | - |
dc.contributor.nonIdAuthor | Cui, Chang-hao | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | ginsenosides | - |
dc.subject.keywordAuthor | dammarane-type triterpene saponin | - |
dc.subject.keywordAuthor | ginsenoside MT1 | - |
dc.subject.keywordAuthor | transglycosylation | - |
dc.subject.keywordAuthor | biotransformation | - |
dc.subject.keywordAuthor | biotechnology | - |
dc.subject.keywordPlus | BETA-GLUCOSIDASE | - |
dc.subject.keywordPlus | MINOR GINSENOSIDES | - |
dc.subject.keywordPlus | TRANSGLYCOSYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | NOTOGINSENG | - |
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