Prediction of motor recovery using indirect connectivity in a lesion network after ischemic stroke

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Background: Recovery prediction can assist in the planning for impairment-focused rehabilitation after a stroke. This study investigated a new prediction model based on a lesion network analysis. To predict the potential for recovery, we focused on the next link-step connectivity of the direct neighbors of a lesion. Methods: We hypothesized that this connectivity would contribute to recovery after stroke onset. Each lesion in a patient who had suffered a stroke was transferred to a healthy subject. First link-step connectivity was identified by observing voxels functionally connected to each lesion. Next (second) link-step connectivity of the first link-step connectivity was extracted by calculating statistical dependencies between time courses of regions not directly connected to a lesion and regions identified as first link-step connectivity. Lesion impact on second link-step connectivity was quantified by comparing the lesion network and reference network. Results: The lower the impact of a lesion was on second link-step connectivity in the brain network, the better the improvement in motor function during recovery. A prediction model containing a proposed predictor, initial motor function, age, and lesion volume was established. A multivariate analysis revealed that this model accurately predicted recovery at 3 months poststroke (R (2)& x2004;=& x2004;0.788; cross-validation, R (2)& x2004;=& x2004;0.746, RMSE & x2004;=& x2004;13.15). Conclusion: This model can potentially be used in clinical practice to develop individually tailored rehabilitation programs for patients suffering from motor impairments after stroke.
Publisher
SAGE PUBLICATIONS LTD
Issue Date
2020-05
Language
English
Article Type
Article
Citation

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, v.13, pp.175628642092567

ISSN
1756-2864
DOI
10.1177/1756286420925679
URI
http://hdl.handle.net/10203/274700
Appears in Collection
EE-Journal Papers(저널논문)
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