Protective effects of epicatechin derivatives on the UV light-induced skin cell damages = Epicatechin Derivatives에 의한 피부 광손상 억제효과

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It has been known that green tea and its components possess the significant chemopreventive effects against chemical carcinogens- and photo-caused skin tumor formation. In this study, the protective effects of green tea epicatechins (EC, EGC, ECG, EGCG) on the UV-induced skin damage (photoaging) were studied in guinea pig, hairless mouse and human dermal fibroblast culture. The UVB-induced lipid peroxidation and erythema were significantly reduced in the epicatechins-treated group. EGCG showed the strongest effect among tested. Amount of lipid peroxides produced in control and EGCG treated group were 838±144 and 286±57 nmol/mg protein 18 hours after UV-irradiation, respectively. The erythema relative index of the control and the EGCG treated group was 223±25 and 124±22 at 16 hours after UV-irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagenase secretion and collagenase mRNA levels in fibroblast culture. The nuclear transcription factors NF-kB and AP-1 binding activities were also inhibited by EGCG treatment.
Advisors
Yang, Kyu-Hwan양규환
Description
한국과학기술원 : 생물과학과,
Publisher
한국과학기술원
Issue Date
2000
Identifier
157740/325007 / 000955081
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생물과학과, 2000.2, [ ix, 54 p. ]

Keywords

Aging; Skin; EGCG; Green tea; UV; 자외선; 노화; 피부; 에피갈로카테킨갈레이트; 녹차

URI
http://hdl.handle.net/10203/27468
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=157740&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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