Targeted delivery of a human Bcl-2-specific protein binder effectively induces apoptosis of cancer cells

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dc.contributor.authorSohn, Yoo-Kyoungko
dc.contributor.authorKim, Hak-Sungko
dc.date.accessioned2020-05-20T08:20:05Z-
dc.date.available2020-05-20T08:20:05Z-
dc.date.created2020-05-18-
dc.date.created2020-05-18-
dc.date.created2020-05-18-
dc.date.issued2020-05-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.526, no.2, pp.447 - 452-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/274244-
dc.description.abstractBcl-2 family proteins are critical switches to control cell death and survival, and Bcl-2 is a key regulator in pro-survival signaling, causing various diseases including cancers. Bcl-2 has drawn a considerable attention as a potential target for developing a pro-apoptotic agent for cancers. We here present the development of a specific protein binder against human Bcl-2 and its cytosolic delivery to effectively induce apoptosis of cancer cells. The protein binder composed of leucine-rich repeat modules was selected for human Bcl-2, and its binding affinity was increased up to 60 nM through a modular evolution-based approach. The protein binder was efficiently delivered into cancer cells by an intracellular delivery system using a translocation domain from a bacterial exotoxin, resulting in a strong suppression of anti-apoptotic signaling in cancer cells. Our results demonstrate that the human Bcl-2-specific protein binder can act as a potent therapeutic agent for cancers.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleTargeted delivery of a human Bcl-2-specific protein binder effectively induces apoptosis of cancer cells-
dc.typeArticle-
dc.identifier.wosid000530031800025-
dc.identifier.scopusid2-s2.0-85082523018-
dc.type.rimsART-
dc.citation.volume526-
dc.citation.issue2-
dc.citation.beginningpage447-
dc.citation.endingpage452-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2020.03.113-
dc.contributor.localauthorKim, Hak-Sung-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorBcl-2-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorProtein binder-
dc.subject.keywordAuthorRepebody-
dc.subject.keywordAuthorCytosolic delivery-
dc.subject.keywordAuthorCancer cells-
dc.subject.keywordPlusBCL-2-
dc.subject.keywordPlusREPEBODY-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusBCL-X(L)-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusDOMAIN-
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