Multiplexed detection of cardiac biomarkers in serum with nanowire arrays using readout ASIC

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dc.contributor.authorZhang, Guo-Junko
dc.contributor.authorChai, Kevin Tshun Chuanko
dc.contributor.authorLuo, Henry Zhan Hongko
dc.contributor.authorHuang, Joon Minko
dc.contributor.authorTay, Ignatius Guang Kaiko
dc.contributor.authorLim, Andy Eu-Jinko
dc.contributor.authorJe, Minkyuko
dc.date.accessioned2020-04-14T01:20:07Z-
dc.date.available2020-04-14T01:20:07Z-
dc.date.created2020-04-09-
dc.date.issued2012-05-
dc.identifier.citationBIOSENSORS & BIOELECTRONICS, v.35, no.1, pp.218 - 223-
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/10203/273885-
dc.description.abstractEarly detection of cardiac biomarkers for diagnosis of heart attack is the key to saving lives. Conventional method of detection like the enzyme-linked immunosorbent assay (ELISA) is time consuming and low in sensitivity. Here, we present a label-free detection system consisting of an array of silicon nanowire sensors and an interface readout application specific integrated circuit (ASIC). This system provides a rapid solution that is highly sensitive and is able to perform direct simultaneous-multiplexed detection of cardiac biomarkers in serum. Nanowire sensor arrays were demonstrated to have the required selectivity and sensitivity to perform multiplexed detection of 100 fg/ml troponin T, creatine kinase MM, and creatine kinase MB in serum. A good correlation between measurements from a probe station and the readout ASIC was obtained. Our detection system is expected to address the existing limitations in cardiac health management that are currently imposed by the conventional testing platform, and opens up possibilities in the development of a miniaturized device for point-of-care diagnostic applications.-
dc.languageEnglish-
dc.publisherELSEVIER ADVANCED TECHNOLOGY-
dc.titleMultiplexed detection of cardiac biomarkers in serum with nanowire arrays using readout ASIC-
dc.typeArticle-
dc.identifier.wosid000305036000033-
dc.identifier.scopusid2-s2.0-84862826075-
dc.type.rimsART-
dc.citation.volume35-
dc.citation.issue1-
dc.citation.beginningpage218-
dc.citation.endingpage223-
dc.citation.publicationnameBIOSENSORS & BIOELECTRONICS-
dc.identifier.doi10.1016/j.bios.2012.02.052-
dc.contributor.localauthorJe, Minkyu-
dc.contributor.nonIdAuthorZhang, Guo-Jun-
dc.contributor.nonIdAuthorChai, Kevin Tshun Chuan-
dc.contributor.nonIdAuthorLuo, Henry Zhan Hong-
dc.contributor.nonIdAuthorHuang, Joon Min-
dc.contributor.nonIdAuthorTay, Ignatius Guang Kai-
dc.contributor.nonIdAuthorLim, Andy Eu-Jin-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorSilicon nanowire array-
dc.subject.keywordAuthorBiosensors-
dc.subject.keywordAuthorCardiac biomarkers-
dc.subject.keywordAuthorSerum-
dc.subject.keywordAuthorMultiplexed detection-
dc.subject.keywordAuthorApplication specific integrated circuit-
dc.subject.keywordPlusSILICON NANOWIRE-
dc.subject.keywordPlusELECTRICAL DETECTION-
dc.subject.keywordPlusDNA HYBRIDIZATION-
dc.subject.keywordPlusINTERFACE-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusMARKERS-
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