IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects

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Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that has been reported thus far(1). The mechanism of celastrol's leptin-sensitizing and antiobesity effects has not yet been elucidated. In this study, we identified interleukin-1 receptor 1 (IL1R1) as a mediator of celastrol's action by using temporally resolved analysis of the hypothalamic transcriptome in celastrol-treated DIO, lean, and db/db mice. We demonstrate that IL1R1-deficient mice are completely resistant to the effects of celastrol in leptin sensitization and treatment of obesity, diabetes, and nonalcoholic steatohepatitis. Thus, we conclude that IL1R1 is a gatekeeper for celastrol's metabolic actions.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2019-04
Language
English
Article Type
Article
Citation

NATURE MEDICINE, v.25, no.4, pp.575 - +

ISSN
1078-8956
DOI
10.1038/s41591-019-0358-x
URI
http://hdl.handle.net/10203/272648
Appears in Collection
MA-Journal Papers(저널논문)
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