march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos

Cited 1 time in webofscience Cited 0 time in scopus
  • Hit : 112
  • Download : 72
MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in zebrafish embryos. We found that march5 transcripts were of maternal origin and evenly distributed at the 1-cell stage, except for the mid-blastula transition, with expression predominantly in the developing central nervous system at later stages of embryogenesis. Overexpression of march5 impaired convergent extension movement during gastrulation, resulting in reduced patterning along the dorsoventral axis and alterations in the ventral cell types. Overexpression and knockdown of march5 disrupted the organization of the developing telencephalon and diencephalon. Lastly, we found that the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBP alpha, Staf, Znf143a, and Znf76. These results demonstrate the essential role of March5 in the development of zebrafish embryos.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2020-01
Language
English
Article Type
Article
Citation

MOLECULES AND CELLS, v.43, no.1, pp.76 - 85

ISSN
1016-8478
DOI
10.14348/molcells.2019.0210
URI
http://hdl.handle.net/10203/272433
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
000510613200008.pdf(1.89 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 1 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0