DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Wonkyong | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.date.accessioned | 2020-01-31T09:20:39Z | - |
dc.date.available | 2020-01-31T09:20:39Z | - |
dc.date.created | 2019-10-14 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | RNA BIOLOGY, v.17, no.2, pp.176 - 187 | - |
dc.identifier.issn | 1547-6286 | - |
dc.identifier.uri | http://hdl.handle.net/10203/271983 | - |
dc.description.abstract | RpoS is a key regulator of general stress responses in Escherichia coli. Its expression is post-transcriptionally up-regulated by the small RNAs (sRNAs), ArcZ, DsrA and RprA, through sRNA-rpoS mRNA interactions. Although overexpression of the sRNA, CyaR, was reported to down-regulate rpoS expression, how CyaR regulates rpoS has not been determined. Here, we report that CyaR represses rpoS expression by base-pairing with a region next to the ArcZ binding site in the 5MODIFIER LETTER PRIME UTR of rpoS mRNA and that CyaR expression itself is down-regulated by ArcZ through sRNA-sRNA interaction. The short form of ArcZ, but not the full-length form, can base-pair with CyaR. This ArcZ-CyaR interaction triggers degradation of CyaR by RNase E, alleviating the CyaR-mediated rpoS repression. These results suggest that ArcZ not only participates in rpoS translation as an activator, but also acts as a regulator of the reciprocally acting CyaR, maximizing its rpoS-activating effect. | - |
dc.language | English | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | Mechanism for coordinate regulation of rpoS by sRNA-sRNA interaction in Escherichia coli | - |
dc.type | Article | - |
dc.identifier.wosid | 000488175100001 | - |
dc.identifier.scopusid | 2-s2.0-85074282726 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 176 | - |
dc.citation.endingpage | 187 | - |
dc.citation.publicationname | RNA BIOLOGY | - |
dc.identifier.doi | 10.1080/15476286.2019.1672514 | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Small RNAs | - |
dc.subject.keywordAuthor | ArcZ | - |
dc.subject.keywordAuthor | CyaR | - |
dc.subject.keywordAuthor | rpoS | - |
dc.subject.keywordAuthor | post-transcriptional regulation | - |
dc.subject.keywordPlus | GENERAL STRESS-RESPONSE | - |
dc.subject.keywordPlus | TARGET MESSENGER-RNA | - |
dc.subject.keywordPlus | BIOFILM FORMATION | - |
dc.subject.keywordPlus | ENVELOPE STRESS | - |
dc.subject.keywordPlus | SILENCING MECHANISMS | - |
dc.subject.keywordPlus | POSITIVE REGULATION | - |
dc.subject.keywordPlus | STATIONARY-PHASE | - |
dc.subject.keywordPlus | HFQ | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
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