Mechanism for coordinate regulation of rpoS by sRNA-sRNA interaction in Escherichia coli

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dc.contributor.authorKim, Wonkyongko
dc.contributor.authorLee, Younghoonko
dc.date.accessioned2020-01-31T09:20:39Z-
dc.date.available2020-01-31T09:20:39Z-
dc.date.created2019-10-14-
dc.date.issued2020-02-
dc.identifier.citationRNA BIOLOGY, v.17, no.2, pp.176 - 187-
dc.identifier.issn1547-6286-
dc.identifier.urihttp://hdl.handle.net/10203/271983-
dc.description.abstractRpoS is a key regulator of general stress responses in Escherichia coli. Its expression is post-transcriptionally up-regulated by the small RNAs (sRNAs), ArcZ, DsrA and RprA, through sRNA-rpoS mRNA interactions. Although overexpression of the sRNA, CyaR, was reported to down-regulate rpoS expression, how CyaR regulates rpoS has not been determined. Here, we report that CyaR represses rpoS expression by base-pairing with a region next to the ArcZ binding site in the 5MODIFIER LETTER PRIME UTR of rpoS mRNA and that CyaR expression itself is down-regulated by ArcZ through sRNA-sRNA interaction. The short form of ArcZ, but not the full-length form, can base-pair with CyaR. This ArcZ-CyaR interaction triggers degradation of CyaR by RNase E, alleviating the CyaR-mediated rpoS repression. These results suggest that ArcZ not only participates in rpoS translation as an activator, but also acts as a regulator of the reciprocally acting CyaR, maximizing its rpoS-activating effect.-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.titleMechanism for coordinate regulation of rpoS by sRNA-sRNA interaction in Escherichia coli-
dc.typeArticle-
dc.identifier.wosid000488175100001-
dc.identifier.scopusid2-s2.0-85074282726-
dc.type.rimsART-
dc.citation.volume17-
dc.citation.issue2-
dc.citation.beginningpage176-
dc.citation.endingpage187-
dc.citation.publicationnameRNA BIOLOGY-
dc.identifier.doi10.1080/15476286.2019.1672514-
dc.contributor.localauthorLee, Younghoon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorSmall RNAs-
dc.subject.keywordAuthorArcZ-
dc.subject.keywordAuthorCyaR-
dc.subject.keywordAuthorrpoS-
dc.subject.keywordAuthorpost-transcriptional regulation-
dc.subject.keywordPlusGENERAL STRESS-RESPONSE-
dc.subject.keywordPlusTARGET MESSENGER-RNA-
dc.subject.keywordPlusBIOFILM FORMATION-
dc.subject.keywordPlusENVELOPE STRESS-
dc.subject.keywordPlusSILENCING MECHANISMS-
dc.subject.keywordPlusPOSITIVE REGULATION-
dc.subject.keywordPlusSTATIONARY-PHASE-
dc.subject.keywordPlusHFQ-
dc.subject.keywordPlusTRANSLATION-
dc.subject.keywordPlusEXPRESSION-
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